•Why it earns a slot
The Sign of the Four introduced Tonga and Jonathan Small as among Doyle's most vividly drawn antagonists, established Watson's marriage subplot that shapes the entire Holmes canon, and contains Holmes's famous maxim that when the impossible is eliminated whatever remains, however improbable, must be the truth.
Sherlock Holmes and Dr. Watson are hired by Mary Morstan, whose father vanished years ago and who has been receiving mysterious pearls from an unknown sender. The investigation leads them through murder, a stolen Indian treasure, and a river chase across the Thames, ultimately unraveling a conspiracy rooted in the 1857 Indian Mutiny. Watson falls in love with Mary along the way, and the treasure itself is lost forever when the captured fugitive scatters it into the river.
This distillation is written from the freely available original, which is always the better read when you have the time: gutenberg.org.